Manchester United manager, Erik ten Hag, has not taken four players for their tour of the United States.
They are Fred, Alex Telles, Eric Bailly and Tyrell Malacia.
Fred, who is being linked with a move away, has been left behind for what United described as “a personal issue”.
However, the Brazil midfielder “is expected to join up with the rest of the squad shortly”.
Telles and Bailly will also not be with the squad, as they look to seal transfers away from Old Trafford.
Telles, who spent last season on loan at Sevilla, is on the verge of joining Saudi Pro League side Al-Nassr.
Bailly is still searching for a new club, while Malacia is recovering from injury.