Domestic football in England returns after the March international break with the FA Cup.
The competition is now in the quarter-final stages and teams will be fighting to secure a place in the final four.
Manchester City, which won the Carabao Cup final before the break, will welcome Liverpool.
Arsenal is away to Southampton and Chelsea hosts Port Vale.
Shearer told BetFair: “Man City vs Liverpool: Prediction – Manchester City win.
“Chelsea vs Port Vale: Prediction – Chelsea win.
“Southampton vs Arsenal: Prediction – Arsenal win.
“West Ham vs Leeds: Prediction – West Ham win.”