Manchester United manager, Ruben Amorim, is set to be without two members of his squad for the trip to Tottenham Hotspur on Saturday.
Kobbie Mainoo and Lisandro Martinez will miss the early kick-off this weekend.
Mainoo has not started a league game this season and was left on the bench for the 2-2 draw away to Nottingham Forest last Saturday.
Martinez has returned to full training last week, but he will not be rushed back.
Both players were not part of the United squad that travelled to London on Friday afternoon.
However, 18-year-old academy midfielder Jack Fletcher is set to be included in United’s matchday squad for the first time this season.